Price TBA

For GDCh members

Not yet a member?

Price TBA

For non-members

Chemical Development and Scale-up in the Fine Chemical and Pharmaceutical Industries

Course-ID: 907/23

Highlights

Process R & D

Industrial Synthesis

Optimisation

Kg to tonne scale

Process Safety

Goals & Content

Chemical process development is generally not taught as part of degree courses in higher education; the conversion of a synthetic route used for making milligram or gram quantities of a chemical into a process for manufacturing multi-kilogram and tonne quantities is typically learnt “on the job” by chemists in industry.


For many years, little chemical development work was published in the literature, until the establishment of the Organic Process R & D journal by Dr Trevor Laird (Founder of Scientific Update). Even now, “tricks of the trade” are handed down within individual company organisations, and it can be difficult to gain an awareness of what is involved in chemical development, and of the skills and techniques required to efficiently scale up chemical processes.

This five half-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

About the Course Management

Dr. John Studley
Course Leader

Scientific Update Mayfield

Dr. John Studley Scientific Update, Mayfield (United Kingdom) John Studley joined Scientific Update as Scientific Director in 2018. In 1999 he joined Vertex Pharmaceuticals initially in Medicinal Chemistry and then transferring in to Process Chemistry in 2005, and finally becoming head of process chemistry for Vertex, UK in 2012. After a post doc at the University of Sheffield in 1995-1997 he joined Oxford Asymmetry. His industrial career started at Rhone-Poulenc in 1986, before obtaining a BSc and PhD from the University of Bath.
Dr. Jonathan Mosley

Scientific update

This is what our participants say

Dr. Marius Strunk

Dr. Marius Strunk

Helm AG

5.0

The event exeeded my expectation by far

Dr. Felix Kortmann

Dr. Felix Kortmann

DSM

5.0

Super Kurs für Chemiker im Bereich 10g-1000kg. Auf den Punkt gebrachtes Wissen in lockerer Atmosphäre und mit britischem Humor.

Dr. Guido Marconi

Dr. Guido Marconi

Aptuit (Verona) Srl

5.0

Very good course; great introduction to the fundamental aspects of Chemical Development

Dr. Berend Eggers

Dr. Berend Eggers

Universität Ulm

5.0

Eine sehr gute Einführung in die Herausforderungen der chemischen Prozessentwicklung - gründlich, informativ, praxisnah!

Time Schedule

Day 1 
2:00 p.m. Introduction
3:30 p.m. Coffee break
3:45 p.m. Costing of Chemical Processes
4:30 p.m. Introduction to Problem Session 1
4:45 p.m. Finish of day 1
Day 2
2:00 p.m. Feedback from Problem Session 1
2:15 p.m. The Investigative Approach to Chemical Development
3:45 p.m Coffee break
4:00 p.m. Solvent Effects
4:45 p.m. Introduction to Problem Session 2
5:00 p.m. Finish of day 2
Day 3
2:00 p.m. Feedback from Problem Session 2
2:15 p.m. Statistical Methods of Optimisation
3:30 p.m. Coffee break
3:45 p.m. Analytical Issues in Process R&D
4:45 p.m. Introduction to Problem Session 3
5:00 p.m. Finish of day 3
Day 4
2:00 p.m. Feedback from Problem Session 3
2:15 p.m. Appreciation of Chemical Engineering Concepts
3:00 p.m. Coffee break
3:45 p.m. Work Up
4:30 p.m. Planning For Scale Up
5:15 p.m. Introduction to Problem Sessions 4+5
5:30 p.m. Finish of day 4
Day 5
2:00 p.m. Feedback from Problem Sessions 4+5
2:15 p.m. Crystallisation and Polymorphism
3:30 p.m. Coffee break
3:45 p.m. Emerging Technologies in Process R&D
4:45 p.m. Thermal Hazard Testing and Runaway Reactions
5:45 p.m. Waste Minimisation and Effluent Control
6:30 p.m. End of the course

Target Group

Young chemists who have just started work in industry as development chemists. Organic chemists/medicinal chemists in research and development who would like to gain in appreciation of development and Scale-Up and who are contemplating moving into perhaps chemical development. Development and production chemists in industry who would like to improve efficiency and gain of their insight into alternative approaches to chemical development. Chemical engineers who wish to understand a chemist’s approach to chemical development of batch processes (a good grounding in organic chemistry is important). Students who are about to enter the industry and can obtain company sponsorship.

Contact

Any questions or need for information?

We are happy to hear from you.

Contact

Any questions or need for information?

We are happy to hear from you.