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Chemical Development and Scale-up in the Fine Chemical and Pharmaceutical Industries
Course-ID: IH907
Highlights
Process R & D
Industrial Synthesis
Optimisation
Kg to tonne scale
Process Safety
Goals & Content
Chemical process development is generally not taught as part of degree courses in higher education; the conversion of a synthetic route used for making milligram or gram quantities of a chemical into a process for manufacturing multi-kilogram and tonne quantities is typically learnt “on the job” by chemists in industry.
For many years, little chemical development work was published in the literature, until the establishment of the Organic Process R & D journal by Dr Trevor Laird (Founder of Scientific Update). Even now, “tricks of the trade” are handed down within individual company organisations, and it can be difficult to gain an awareness of what is involved in chemical development, and of the skills and techniques required to efficiently scale up chemical processes.
This five half-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.
About the Course Management
Scientific Update Mayfield
John Studley Scientific Update as Scientific Director in 2018. In 1999 he joined Vertex Pharmaceuticals initially in Medicinal Chemistry and then transferring in to Process Chemistry in 2005, and finally becoming head of process chemistry for Vertex, UK in 2012. After a post doc at the University of Sheffield in 1995-1997 he joined Oxford Asymmetry. His industrial career started at Rhone-Poulenc in 1986, before obtaining a BSc and PhD from the University of Bath.
Scientific Update Mayfield
Jonathan Moseley was most recently Technical Director at CatSci Ltd, an SME CRO which delivers expertise in the development, optimisation and understanding of scale-up processes, including catalytic reactions, across the chemical research, development and manufacturing sectors. He began his career as a medicinal chemist at Merck Sharp and Dohme for a total of six years either side of a PhD at Cambridge, before moving to Zeneca (now AstraZeneca) as a process development chemist in 1996. During this time he worked on pharmaceutical projects in all stages of development from early route selection, large-scale lab and pilot plant scale-up, through to established manufacturing processes, a trend which has continued at CatSci. Since forming CatSci with colleagues in 2011, the scope of this development work has broadened into other sectors of the chemical industry. In addition, he maintains an interest in the application of new technologies to chemical process development. He is now an associate of Scientific Update.
This is what our participants say
Dr. Marius Strunk
Helm AG
5.0
The event exeeded my expectation by far
Dr. Felix Kortmann
DSM
5.0
Super Kurs für Chemiker im Bereich 10g-1000kg. Auf den Punkt gebrachtes Wissen in lockerer Atmosphäre und mit britischem Humor.
Dr. Guido Marconi
Aptuit (Verona) Srl
5.0
Very good course; great introduction to the fundamental aspects of Chemical Development
Dr. Berend Eggers
Universität Ulm
5.0
Eine sehr gute Einführung in die Herausforderungen der chemischen Prozessentwicklung - gründlich, informativ, praxisnah!
Anna Wolfram
Georg-Speyer-Haus
5.0
This is the ideal course to get up to seep with current standards of GMP scale-up in an industrial setting. Highly recommend this course to anyone who wants to take his expertise in the field to the next level in a relatively short amount of time.
Dr. Andreas Jacob
Continental Reifen GmbH
5.0
Sehr gut vorgetragen und die Materie nahegebracht
Time Schedule
Optional table of contents for your inhouse course | |
---|---|
Course day 1 | |
2:00 p.m. | Introduction |
3:30 p.m. | Coffee break |
3:45 p.m. | Costing of Chemical Processes |
4:30 p.m. | Introduction to Problem Session 1 |
4:45 p.m. | Finish of day 1 |
Course day 2 | |
2:00 p.m. | Feedback from Problem Session 1 |
2:15 p.m. | The Investigative Approach to Chemical Development |
3:45 p.m | Coffee break |
4:00 p.m. | Solvent Effects |
4:45 p.m. | Introduction to Problem Session 2 |
5:00 p.m. | Finish of day 2 |
Course day 3 | |
2:00 p.m. | Feedback from Problem Session 2 |
2:15 p.m. | Statistical Methods of Optimisation |
3:30 p.m. | Coffee break |
3:45 p.m. | Analytical Issues in Process R&D |
4:45 p.m. | Introduction to Problem Session 3 |
5:00 p.m. | Finish of day 3 |
Course day 4 | |
2:00 p.m. | Feedback from Problem Session 3 |
2:15 p.m. | Appreciation of Chemical Engineering Concepts |
3:00 p.m. | Coffee break |
3:45 p.m. | Work Up |
4:30 p.m. | Planning For Scale Up |
5:15 p.m. | Introduction to Problem Sessions 4+5 |
5:30 p.m. | Finish of day 4 |
Course day 5 | |
2:00 p.m. | Feedback from Problem Sessions 4+5 |
2:15 p.m. | Crystallisation and Polymorphism |
3:30 p.m. | Coffee break |
3:45 p.m. | Emerging Technologies in Process R&D |
4:45 p.m. | Thermal Hazard Testing and Runaway Reactions |
5:45 p.m. | Waste Minimisation and Effluent Control |
6:30 p.m. | End of the course |
Target Group
Young chemists who have just started work in industry as development chemists. Organic chemists/medicinal chemists in research and development who would like to gain in appreciation of development and Scale-Up and who are contemplating moving into perhaps chemical development. Development and production chemists in industry who would like to improve efficiency and gain of their insight into alternative approaches to chemical development. Chemical engineers who wish to understand a chemist’s approach to chemical development of batch processes (a good grounding in organic chemistry is important). Students who are about to enter the industry and can obtain company sponsorship.
Price on request
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